Dry suspension formulation of taste masked antibiotic drug for pediatric use.

Dry suspension is commercial dry mixtures that require addition of water at the time of dispensing. The major consequence of the bitter taste is to restrict greatly the further development of oral preparations and clinical applications of these drugs. People wish to take effective drugs that have a nice taste can be administered easily. Accordingly, it is important to mask the unpalatable taste of a drug in order to improve the product quality. The solvent evaporation process is used for microencapsulation which is carried out in a liquid manufacturing vehicle. Eudragit L100 is used as taste masking agent. FT-IR study shows that there is no significant interactions occurring between drug and excipients. The suspension prepared was evaluated for various parameters like sedimentation volume, degree of flocculation, drug content and In-vitro dissolution time. All the parameters were found to be within limits. When the results were compared with marketed preparation suspension was found to be better with respect to marketed preparation.

Levocetirizine orodispersible tablet by direct compression method.

Orodispersible tablets are those that dissolve or disintegrate quickly in the oral cavity, resulting in solution or suspension. Allergic rhinitis is a high-prevalence chronic respiratory disease with a negative impact on the subject’s quality of life, work activities, productivity or school performance as well as on healthcare costs. Because of its benign nature, the importance of this condition is often underestimated. In the present study orodispersible tablet of antihistaminic agent was prepared by direct compression method using crosspovidone, Crosscarmellose and Indion 414, as superdisintegrants. FT-IR study shows that there is no significant interactions occur between drug and excipient. The tablets prepared were evaluated for various parameters like various density parameters, thickness, hardness, friability, disintegration time, wetting time and In-vitro dissolution time. All the parameters were found to be within limits. The developed formulation of levocetirizine batch F8 (10% Indion 414) showed good palatability and dispersed within 30 seconds as compare to crosscarmellose sodium and crosspovidone. When the results were compared with that of convectional tablets was found to be better with respect to simple manufacturing and allergic rhinitis.